INTRODUCTION
Cadmium is one of the most toxic elements that accumulate in the environment through agricultural and industrial pollutants. Cadmium may enter the human population through food and beverages, drinking water, air, and cigarette smoking. This heavy metal has a long biological half-life, mainly due to its slow elimination rate from the body (1). Studies have shown that behavioral changes following exposure to heavy metals are associated with hippocampal function (1,2). Neurotransmitter disorders and factors that can be associated with abduction and consequences can be associated with abduction and consequences (3). Depression and anxiety are among the most common psychiatric disorders that affect the quality of life of an individual (4). Anxiety is a genetic and environmental factor in this species and a factor that is mainly characterized by mood (5). Treatments for depression and anxiety are multimodal, including medications, psychotherapy, or a combination of the two (3), but each has varying degrees of effectiveness. However, physical activity has been shown to be associated with a reduced risk of morbidity and mortality (4). According to sports psychologists, the best way to propose a suitable, low-cost, minimally invasive, and safe treatment is as one of the water and even dangerous and mildly harmful methods (6). However, the treatment of depression and exercise with sports activities and mobility does not occur alone but can play an important and key role in reducing their risks along with psychotherapy and medication (8,11). One of the natural compounds that has been recently studied is honey. Pollen is a collection of pollen particles that are combined with nectar and honeybee saliva and become a uniform substance (12). Studies indicated that honey has antioxidant properties and contains various polyphenolic compounds that are effective in treating injury and regulating and balancing the work of neurotransmitters and their receptors in different areas of the brain, especially the hippocampus, where it can be used.

METHODS
In this experimental study, 25 healthy male Sprague-Dawley rats, approximately eight weeks old and weighing approximately 250 grams, were purchased as a statistical sample. After one week of adaptation to the laboratory environment, the rats were weight-matched and randomly divided into five equal groups (n = 5), including the healthy control (HC), cadmium (Cd), cadmium-pollen (Cd-PO), cadmium-high-intensity interval training group (Cd-HIIT-Glum-Cd-HIIT), and cadmium-HIIT-PO groups (16,17,18). High-intensity interval training was performed for eight weeks, three sessions per week, with an intensity of 80 to 110% (VO2max), and before and after each training session, a 5-minute warm-up and cool-down were performed at an intensity of 50 to 60% VO2max (19 mg/cc, 200 g). Chloride (dissolved in drinking water, 40 mg/kg/w/d) was administered daily (20,18). For all study groups, behavioral tests (anxiety-like and depression-like) were measured using the elevated plus maze test and forced swimming (21,22). A total of 48 hours after the training session, supplementation with pollen, and administration of cadmium bantam and xylosine, the mice were anesthetized. Then, hippocampal tissue was carefully removed for cadmium measurement and stored in a freezer at -80°C. A significance level of P<0.05 was used.

RESULTS
The results of the independent t-test showed that the levels of cadmium in the brains of rats in the healthy control group were significantly lower than in the other groups (P=0.001). These results also indicated that the extent of these changes in the cadmium group was significantly higher than in the exercise-pollen group (P=0.031). However, there was no significant difference between the pollen group and the exercise group (P<0.05). The results of the Mann-Whitney test for anxiety-like behaviors showed that the duration of presence in the plus maze in the healthy control group was significantly higher than in the cadmium, pollen, exercise group, and pollen-exercise groups (P=0.009). The results of this test also showed a significant difference in the pollen group (P=0.021), exercise group (P=0.016), and pollen-exercise group (P=0.009) compared to the cadmium group. The Mann-Whitney test for the number of times entering the open arm of the maze was significant for the control group compared to the cadmium group (P = 0.009) but not for the pollen, training, and pollen + training groups. Moreover, the results of this test were significantly higher for the pollen (P=0.028), the training (P=0.007), and the pollen-training groups compared to the cadmium group (P=0.005). The results of the independent t-test showed that the duration of immobility in the cadmium, pollen, training, and training-pollen groups was significantly higher compared to the control group (P=0.001). Moreover, the results of this test showed a significant decrease in the duration of immobility in the pollen, training, and pollen-training groups compared to the cadmium group (P=0.001).

CONCLUSION
According to the results of the present study, eight weeks of intense interval training and pollen consumption significantly reduced anxiety-like behaviors and depression. However, intense interval training combined with pollen consumption was unable to reduce anxiety-like behaviors and depression significantly. It appears that interval training and pollen consumption, when used alone, may be effective in improving brain function and reducing behavioral disorders in the study subjects by increasing cerebral blood flow, reducing inflammatory factors, decreasing free radicals, and enhancing antioxidant capacity. However, further research is needed in this field.

Ethical Considerations
Compliance with ethical guidelines
All ethical principles for working with animals were approved in accordance with the Helsinki Declaration and under the supervision of the

Ethics Committee of the Islamic Azad University of Boroujerd Branch, with the Code: IR.IAU.B.REC.1402.115.

Funding
No financial support was provided for this research.

Authors' Contributions
All authors participated in the design, implementation, data analysis, and writing of all parts of the study.

Conflict of Interest
The authors declare that there are no conflicts of interest.

Acknowledgments
The authors express their gratitude and appreciation to all those who contributed to this research.