Introduction: Portal Vein Thrombosis (PVT) is a rare and disabling condition. The most common underlying causes of PVT is pancreatitis, myeloproliferative disorders, liver carcinoma and lack of anticoagulant (thrombophilia). It can be observed in the patients who have undergone spleenectomy for any reason such as β-thalassemia major. Portal vein thrombosis treatment is usually conservative.

Case Report: The case was a 70-year-old woman who came without a history or risk-factor but with abdominal pain and acute anorexia. Clinical examination, ultrasonography and CT scan diagnosed portal vein thrombosis and spleen vein thrombosis enhancing to mesenteric veins. Given the unresponsiveness of the case to the routine anti-coagulant treatments and not having appropriate criteria for surgical treatment, she was referred to the traditional medicine clinic. In initial examination, venous blockage was diagnosed and the patient underwent phlebotomy and traditional medicine pharmacotherapy. After three weeks, all the symptoms of the patient were relieved as depicted in ultrasonography and clinical examinations.

Conclusion: Given the hazardous complications of portal vein thrombosis and lack of a definitive treatment protocol, it seems that the Iranian Traditional Medicine can be contributory to its treatment.