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Volume 11, Issue 4 (3-2022)
cmja 2022, 11(4): 330-345 |
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Sistani Karampour N, Bagheri M J, Khorsandi L S, Dehghan Mohammadi Z, Salehcheh M, Honarmand H. Investigating the Safety of Bee Pollen on Performance, Oxidative Stress, and Histopathological Changes in the Liver, Kidney, and Pancreas of Rats. cmja 2022; 11 (4) :330-345
URL: http://cmja.arakmu.ac.ir/article-1-829-en.html
URL: http://cmja.arakmu.ac.ir/article-1-829-en.html
Neda Sistani Karampour1 
, Mohammad Javad Bagheri2 , Laya Sadat Khorsandi3 , Zeinab Dehghan Mohammadi4 , Maryam Salehcheh 5, Hooman Honarmand2
, Mohammad Javad Bagheri2 , Laya Sadat Khorsandi3 , Zeinab Dehghan Mohammadi4 , Maryam Salehcheh 5, Hooman Honarmand2
1- Department of Pharmacology, Faculty of Pharmacy, Marine Pharmaceutical Sciences Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2- Toxicology Department, Pharmacy faculty, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3- Department of Histology, Faculty of Medicine, Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4- Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
5- Department of Toxicology, Faculty of Pharmacy, Toxicology Research Center, Basic Medical Sciences Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. , maryamsalehcheh@gmail.com
2- Toxicology Department, Pharmacy faculty, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3- Department of Histology, Faculty of Medicine, Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4- Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
5- Department of Toxicology, Faculty of Pharmacy, Toxicology Research Center, Basic Medical Sciences Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. , maryamsalehcheh@gmail.com
Abstract: (1763 Views)
Objective: The therapeutic effects of bee pollen have already been proven in various studies, but toxicity studies in this field are limited. Therefore, in this study, the possible toxicity effects of hydroalcoholic extract of flower pollen on liver, kidney, and pancreatic tissues of male rats are investigated.
Methods: Fourteen male rats were divided into two groups of seven: the first group received 800 mg/kg hydroalcoholic extract of bee pollen, and the second group received 0.5 mL/100 g normal saline intraperitoneally for 1 day. Then, their livers, kidney, pancreas, and oxidative stress biomarkers were evaluated. In addition, pieces of liver, kidney, and pancreatic tissues were examined histopathologically.
Results: Blood urea nitrogen (BUN) (P =0.0212), aspartate aminotransferase (AST) enzymes (P =0.0344), and malondialdehyde (MDA) biomarker (P =0.018) of kidney tissue were significantly decreased in the hydroalcoholic extract of bee pollen group compared to the control group. The glutathione (GSH) biomarker of kidney tissue showed a significant increase in this group compared to the control group (P =0.0031). The other evaluated parameters were not significantly different between the two groups (P> 0.05). Histopathologically, no deleterious and toxicity effects were observed in the tissues.
Conclusion: Bee pollen has therapeutic properties and, as a nutrient, can be useful and effective for humans. In this study, this substance did not have toxicity effects on the liver, kidney, and pancreas and even protected vital organs in oxidative stress conditions. However, more research is needed to prove the toxicity of this valuable substance and to ensure its safety.
Methods: Fourteen male rats were divided into two groups of seven: the first group received 800 mg/kg hydroalcoholic extract of bee pollen, and the second group received 0.5 mL/100 g normal saline intraperitoneally for 1 day. Then, their livers, kidney, pancreas, and oxidative stress biomarkers were evaluated. In addition, pieces of liver, kidney, and pancreatic tissues were examined histopathologically.
Results: Blood urea nitrogen (BUN) (P =0.0212), aspartate aminotransferase (AST) enzymes (P =0.0344), and malondialdehyde (MDA) biomarker (P =0.018) of kidney tissue were significantly decreased in the hydroalcoholic extract of bee pollen group compared to the control group. The glutathione (GSH) biomarker of kidney tissue showed a significant increase in this group compared to the control group (P =0.0031). The other evaluated parameters were not significantly different between the two groups (P> 0.05). Histopathologically, no deleterious and toxicity effects were observed in the tissues.
Conclusion: Bee pollen has therapeutic properties and, as a nutrient, can be useful and effective for humans. In this study, this substance did not have toxicity effects on the liver, kidney, and pancreas and even protected vital organs in oxidative stress conditions. However, more research is needed to prove the toxicity of this valuable substance and to ensure its safety.
Type of Study: Research |
Subject:
Medicinal Plants
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