TY - JOUR T1 - Effects of garlic extract, olive leaf extract, nettle extract on serum inflammatory markers hsCRP and IL-6 and TNF-α in rats with diabetes TT - بررسی اثرات عصاره سیر، عصاره برگ گزنه و عصاره زیتون بر سطح سرمی فاکتورهای التهابی پروتئین التهابی C و اینترلوکین-6 و فاکتور نکروز توموری آلفا در رت های مبتلا به دیابت JF - CMJA JO - CMJA VL - 6 IS - 1 UR - http://cmja.arakmu.ac.ir/article-1-242-en.html Y1 - 2016 SP - 1452 EP - 1460 KW - Inflammation KW - hsCRP and IL -6 KW - TNF-α KW - Diabetes N2 - Introduction: It has been demonstrated that the inflammatory markers such as IL-6, TNF-α and CRP are increased in STZ-diabetic rats. The present study is to investigate the effects of medicinal plants used in traditional medicine, including garlic extract; nettle leaves extract and olive extract on serum hsCRP and IL-6 and TNF-α on the rats with diabetes. Methods: Diabetes was induced in male wistar rats by single injection streptozotocin (60 mg/kg). Garlic extract, nettle leaves extract and olive extract were used one day after induction of diabetes until three weeks after STZ-diabetes induction. In this study the animals were divided into five groups: control, diabetic, diabetic + garlic extract (50 mg / kg), diabetes + Nettle leaf extract (30 mg / kg), and diabetes + Olive extract (30 mg / kg). After 21 days, serum levels of inflammatory factors were measured using ELISA kits. Results: The results showed that the serum levels of hsCRP and IL-6 and TNF-α in the target groups, the use of medicinal plants extracts, as compared to untreated diabetics have significantly decreased. Conclusion: The results showed that administration of garlic extract, nettle extract and olive extract significantly attenuated levels inflammatory markers such as IL-6, TNF-α and CRP in diabetic rats. M3 ER -