TY - JOUR T1 - Effect of Resistance and Aerobic Exercises with Different Intensities on BDNF & TrkB Receptor Gene Expression in Ovariectomized Mice TT - تأثیر تمرینات مقاومتی و هوازی با شدت‌های مختلف بر بیان ژن BDNF و گیرندۀ TrkB در موش‌های اوارکتومی‌شده JF - CMJA JO - CMJA VL - 8 IS - 2 UR - http://cmja.arakmu.ac.ir/article-1-574-en.html Y1 - 2018 SP - 2304 EP - 2316 KW - Resistance exercise KW - Swimming exercise KW - BDNF & TrkB KW - Hippocampus KW - Ovariectomy N2 - Introduction: This study aimed to investigate the effect of resistance and aerobic exercises with different intensities on BDNF & TrkB receptor gene expression in ovariectomized mice. Methods: Sixty 6 to 8-month old mice with average weight of 230 ±10 g were randomly divided into six 10-member groups: ovariectomized + high-intensity resistance exercises, ovariectomized + low-intensity resistance exercises, ovariectomized + high-intensity swimming exercises, ovariectomized + low-intensity swimming exercises, control and sham. The animals in the exercise groups performed low- and high-intensity exercises for 8 weeks, one session a day, 3 days a week. After the training protocol, the animals' hippocampus tissues were removed. Quantitative Real-time RT-PCR was used to determine the changes occurred in BDNF and TrkB gene expression. The data were analyzed by SPSS 23 using ANOVA at the significant level of α = 0.05. Results: BDNF gene expression significantly increased in the high-intensity resistance exercise group (P<0.036), but the difference was not significant in the low-intensity resistance exercise (P<0.975), high-intensity swimming exercise (P<0.141) and low-intensity swimming groups (P = 0.998) compared to the control group. TrkB receptor gene expression increased in the high-intensity resistance exercise (P<0.036) and swimming exercise groups (P<0.002), but the difference was not significant in the low-intensity resistance exercise (P<0.442) and swimming exercise groups (P<0.688). Conclusion: High-intensity swimming exercise increased BDNF and TrkB receptor gene expression. However, high-intensity resistance exercise is likely to offer better results. M3 ER -