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Volume 16, Issue 1 (4-2026)
cmja 2026, 16(1): 1-3 |
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Didehdar M, Khodashenas S. Letter to Editor: Urgent Need for Genomic Surveillance of Candida Auris in Iran. cmja 2026; 16 (1) :1-3
URL: http://cmja.arakmu.ac.ir/article-1-1078-en.html
URL: http://cmja.arakmu.ac.ir/article-1-1078-en.html
1- Department of Parasitology and Medical Mycology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran , didehdar_m@yahoo.com
2- Department of Parasitology and Medical Mycology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
2- Department of Parasitology and Medical Mycology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
Abstract: (158 Views)
Letter to Editor: The rising incidence of Candida auris detection within Iranian healthcare facilities poses a substantial challenge to the nation’s infection control strategies. Recent investigations indicate that the majority of isolates identified in Iran belong to clade V, a lineage characterized by pronounced resistance to fluconazole and emerging concerns regarding diminished susceptibility to amphotericin B. This resistance profile significantly restricts therapeutic options and heightens the potential for nosocomial transmission (1)(2).
Despite the clinical significance of this pathogen, many diagnostic laboratories continue to rely on conventional phenotypic identification methods. Such approaches are susceptible to misidentification and fail to provide information on clade classification or the presence of mutations associated with antifungal resistance. Consequently, transmission dynamics and the emergence of resistant clones may remain undetected.
Whole genome sequencing (WGS) offers a robust solution to these limitations. Countries that have integrated WGS into their surveillance frameworks have demonstrated enhanced capabilities in outbreak detection, expedited response measures, and the reinforcement of evidence-based infection control policies. Within the Iranian context, where clade V predominates, genomic surveillance is indispensable for informing the judicious use of antifungal agents and guiding public health interventions (3).
Therefore, it is recommended that Iranian health authorities and academic institutions prioritize the development and implementation of a coordinated national WGS-based surveillance program for Candida auris. Such an initiative would facilitate the early identification of high-risk strains, bolster hospital infection control efforts, and inform policy decisions at the national level.
Despite the clinical significance of this pathogen, many diagnostic laboratories continue to rely on conventional phenotypic identification methods. Such approaches are susceptible to misidentification and fail to provide information on clade classification or the presence of mutations associated with antifungal resistance. Consequently, transmission dynamics and the emergence of resistant clones may remain undetected.
Whole genome sequencing (WGS) offers a robust solution to these limitations. Countries that have integrated WGS into their surveillance frameworks have demonstrated enhanced capabilities in outbreak detection, expedited response measures, and the reinforcement of evidence-based infection control policies. Within the Iranian context, where clade V predominates, genomic surveillance is indispensable for informing the judicious use of antifungal agents and guiding public health interventions (3).
Therefore, it is recommended that Iranian health authorities and academic institutions prioritize the development and implementation of a coordinated national WGS-based surveillance program for Candida auris. Such an initiative would facilitate the early identification of high-risk strains, bolster hospital infection control efforts, and inform policy decisions at the national level.
Keywords: Candida Auris, Iran
Type of Study: Applicable |
Subject:
Clinical Medicine
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