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Volume 12, Issue 1 (In Press 2022)                   cmja 2022, 12(1): 0-0 | Back to browse issues page

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Hoseininejad ٍ, Valipour dehnou V, Ghahramanlou E, Gorzi A. The effect of 8 weeks of aerobic exercise with cinnamon hydroalcoholic extract on arginase and p38 MAPK levels of soleus muscle in diabetic rats. cmja. 2022; 12 (1)
URL: http://cmja.arakmu.ac.ir/article-1-853-en.html
1- Department of Sport Sciences, Literature & Human Sciences Faculty, Lorestan University, Khorramabad, Iran.
2- Department of Sport Sciences, Literature & Human Sciences Faculty, Lorestan University, Khorramabad, Iran , valipour.v@lu.ac.ir
3- College of Health and Human Sciences, Charles Darwin University, Northern Territory, Australia.
4- Sport Sciences Department, Human Sciences faculty, University of Zanjan, Zanjan, Iran.
Abstract:   (41 Views)
Objective: Recently, there is a great interest in combination therapies in the treatment of most diseases. Emerging evidence suggests that the arginase enzyme plays a key role in the complications of diabetes, and that modulating this enzyme may be an appropriate treatment to reduce the complications of the disease. Therefore, the aim of this study was to evaluate the effect of 8 weeks of aerobic exercise with cinnamon hydroalcoholic extract on arginase and P38MAPK levels in soleus muscle of type 2 diabetics rats.
Methods: In this study, 35 eight-week-old male Wistar rats (200-250 g) were equally randomly divided into five groups: control (C), diabetes (D), diabetes and Supplement (DS), diabetes and aerobic exercise (DE) and diabetes, aerobic exercise and supplement (DES). The aerobic exercise program was progressively performed 5 sessions per week for 8 weeks. Rats in DS and DES groups received 200 mg/kg of cinnamon supplement (HACE) daily by gavage, and Rats in groups C and DE received water during this period. Forty-eight hours after the end of the protocols, soleus muscle was isolated and enzymes were measured. To analyze the data one-way analysis of variance was used and Pearson correlation coefficient test was used to examine the relationships between variables and the significance level was set at p < 0.05.
Results: The level of arginase enzyme in group D (1.17±.05) was significantly higher than group C (.53±.08). Also, arginase enzyme level in DES (.67±.09) groups were significantly lower than group D. There was no significant difference in p38MAPK protein level in any of the groups. There was also a significant positive correlation between blood glucose levels and arginase enzyme.
Conclusion: The combination of exercise and cinnamon extract can reduce the level of arginase enzyme. Therefore, due to the fact that many complications of diabetes are associated with an increase in the arginase enzyme, this treatment can be helpful. Since this study has provided convincing information about the positive effects of exercise and cinnamon on the complications of diabetes at the non-clinical level, it can pave the way for clinical trial studies.
     
Type of Study: Applicable | Subject: Medicinal Plants

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