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Mohsen Mousavi Amin 
, Saqqa Farajtabar Behrestaq *1 , Amir Taghipoor , Babisan Askari1 , Fatemeh Zahra Janbarari
, Saqqa Farajtabar Behrestaq *1 , Amir Taghipoor , Babisan Askari1 , Fatemeh Zahra Janbarari
1- , s.faraj.b@iau.ac.ir
Abstract: (623 Views)
Background: Non‐alcoholic fatty liver disease (NAFLD) is associated with increased production/deposition of collagen and extracellular matrix. The aim of this study is to investigate the effect of aerobic exercise and resveratrol on the expression of Fibrillin-1 and Asprosin in adipose tissue of NAFLD rats.
Materials and Methods: In this experimental study, Thirty five Wistar male rats were classified into two groups NAFLD (n=28) and Control-Normal (n=7). NAFLD was induced in rats with high fat diet and then subdivided into 4 subgroups NAFLD, TRNAF, SUPNAF and TRSUPNAF. Training groups have performed a running program on a motor-driven treadmill for eight weeks. Resveratrol (20 mg/kg) was injected into the SUPNAF and TRSUPNAF groups. Forty-eight hours after the last training session, rats were anesthetized; hearts were excised and immediately frozen in liquid nitrogen and stored at -80°C for measuring the indexes. Statistical analysis was performed using a one-way analysis of variance, and significance was accepted at p ≤ 0.05.
Results Induction of NAFLD was associated with increased expression of Fibrillin-1 and Asprosin. Significant reductions of these genes in NAFLDT (p= 0.037, p= 0.047, respectively) and NAFLDTRSV (p= 0.0001; both) groups compared to the NAFLD. Furthermore, the NAFLDTRSV showed significantly lower expression compared to the NAFLDT (p = 0.037, p = 0.047) and NAFLDRSV (p = 0.007, p = 0.026) (p ≤ 0.05).
Conclusion: Exercise training along with resveratrol could improve adipose tissue disorders caused by NAFLD by significantly reducing the expression of fibrillin-1 and asprosin. However, the effect of resveratrol alone is not effective and more research is needed.
Materials and Methods: In this experimental study, Thirty five Wistar male rats were classified into two groups NAFLD (n=28) and Control-Normal (n=7). NAFLD was induced in rats with high fat diet and then subdivided into 4 subgroups NAFLD, TRNAF, SUPNAF and TRSUPNAF. Training groups have performed a running program on a motor-driven treadmill for eight weeks. Resveratrol (20 mg/kg) was injected into the SUPNAF and TRSUPNAF groups. Forty-eight hours after the last training session, rats were anesthetized; hearts were excised and immediately frozen in liquid nitrogen and stored at -80°C for measuring the indexes. Statistical analysis was performed using a one-way analysis of variance, and significance was accepted at p ≤ 0.05.
Results Induction of NAFLD was associated with increased expression of Fibrillin-1 and Asprosin. Significant reductions of these genes in NAFLDT (p= 0.037, p= 0.047, respectively) and NAFLDTRSV (p= 0.0001; both) groups compared to the NAFLD. Furthermore, the NAFLDTRSV showed significantly lower expression compared to the NAFLDT (p = 0.037, p = 0.047) and NAFLDRSV (p = 0.007, p = 0.026) (p ≤ 0.05).
Conclusion: Exercise training along with resveratrol could improve adipose tissue disorders caused by NAFLD by significantly reducing the expression of fibrillin-1 and asprosin. However, the effect of resveratrol alone is not effective and more research is needed.
Type of Study: Research |
Subject:
Physiology
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Complementary Medicine Journal
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