Materials and Methods: This review study was conducted by searching the internet over a two-month period. Of the 40 articles found, 25 articles related to lacrimal gland cancer of the eye and the molecular mechanisms involved. Most of them were published between 2020 and 2025. Then, a list of effective plants in treating eye lacrimal glands cancer was prepared.
Results: The plant species obtained contain natural compounds that can inhibit MYB gene expression through different pathways or prevent tumor metastasis by epithelial-mesenchymal transition in other cancers, except the lacrimal gland cancer. A total of 14 species and two genera from 11 families were found, which are potentially effective for treating LGACC.
Conclusion: Based on the findings, 16 plant species from 11 families were found, which can inhibit MYB gene expression and EMT in cancer cells and tumors except lacrimal glands cancer. No research reported the direct effectiveness of these plants on treating lacrimal glands. Therefore, it is suggested to perform further research regarding the direct effects of these plants on treating lacrimal gland cancer.