Introduction: Pain relief during routine procedures such as inserting IV or intravenous treatment is affected patient satisfaction of care. The aim of this study was to evaluate comparative effects of quinine plant and lidocaine on pain of venipuncture respectively.

Methods: This study was an interventional study in 1394. Samples were selected by convenience sampling from patients referred to the hospital emergency department. Informed consent was obtained from the samples. There were divided into three groups randomly, intervention by quinine, intervention of lidocaine and control. 10 puffs of lidocaine 10% for 15 minutes in lidocaine group were applied on the position of the vessel up to 3 cm diameter circular. 10 puffs alcoholic extract quinine 10% for 15 minutes in quinine group was used before taking on the position of the vessel. The data gathering tools includes Pain Visual Analogue Scale, and anxiety analogue scale. The data were analyzed via SPSS version 16 by chi-square, Fisher exact, Independent t-test, paired sample t-test and ANOVA.

Results: There is no statistically significant difference in the three groups between pain and anxiety scale scores. Despite the pain was not significant statistically in all three groups, but the mean pain score in the lidocaine group (M=3.38) less than quinine (M=4.37) and control groups (m=4.60), respectively.

Conclusion: According to study Quinine and lidocaine are not effective on pain of venipuncture. The pain of venipuncture, especially in emergency situations should seek innovative approaches with strong analgesic and anti-anxiety effect that are easy to use and cause less side effects. Further study and research need in these fields.