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Hamed Fathi, Nooredin Mohammad Shahi, Fatemeh Shaki,
Volume 5, Issue 4 (3-2016)
Abstract

Introduction:AlbiziaJulibrissin, have been used for treatment of insomnia, anxiety and depression in traditional medicine. Considering the adverse effects of chemical drugs used as anti-nausea, in this study we investigated the potential beneficial effects of AlbiziaJulibrissin in reducing nausea in chicken model.

Methods: In this experimental study,AlbiziaJulibrissin was collected from the forests of Mazandaran. Its methanolic extract was prepared using different methods including; succulent, maceration and sonication. Nausea was induced by Copper Sulfate (60 mg/kg, orally) and Ipecac (600 mg/kg, orally) in chickens (6 in each group). The number of Copper Sulfate induced nausea was counted for 50 and Ipecac induced nausea for 20 minutes after administration. Data was analyzed by SPSS using one way ANOVA followed with Tukey test.

Results: Intra peritoneal administration of AlbiziaJulibrissin extracts decreased the number of nausea induced by Copper Sulfate and Ipecac. There was a significant difference with administration of succulent extract in reducing the number of nausea (25±11.6) and (37.3±8) comparing to Ipecac (67.6±10) and Copper Sulfate groups (82±16) (p=0/004). Also, administration of maceration extract significantly reduced the number of nausea (55±5.2) comparing to Copper Sulfate group (82±16) (p=0/014). Extraction with succulent, maceration and sonication methods showed better effects, respectively.

Conclusion: Results showed that the extracts of AlbiziaJulibrissin have an anti-nausea activity in chickens, probably due to its sedative effects.


Heydar Mousavi, Hajar Badri, Esmail Najafi, Saeed Parastar, Shahram Nazari,
Volume 14, Issue 1 (4-2024)
Abstract

Introduction: The increase in the resistance of fungal species and the high side effects of antifungal drugs have led researchers to study and find new treatment methods against fungi. This study evaluated the anti-candidacy effects of local and artificial egg whites and compared them with amphotericin B.
Materials and Methods: This study was conducted experimentally in May 2023 in the Microbiology Laboratory of Khalkhal Faculty of Medical Sciences. This research tested the antifungal effects of local and machine chicken egg whites and amphotericin B using the micro broth dilution and zone of inhibition method. In this experiment, Candida albicans species were placed in the vicinity of different concentrations of substances, and the minimum inhibitory concentration (MIC) and minimum fungicide concentration (MFC) of these substances on C. albicans were determined according to the guidelines of the Clinical and Laboratory Standards Institute.
This study has been registered with the ethical code IR. IR.KHALUMS.REC.1401.019 in the Ethics Committee of Khalkhal Faculty of Medical Sciences.
Results: Based on the results of the tests, the MIC of local and machine chicken egg whites on C. albicans was 25%, and their MFC was 50%.  However, in these concentrations, no growth was observed in the presence of amphotericin B. Moreover, the MIC and MFC values of 25 µl of amphotericin B with 75 µl of local and machine egg whites were 3.125% and 6.25%, respectively. The zone of inhibition for C. albicans in the vicinity of local and machine chicken egg white and amphotericin B was 12, 11, and 16 mm, respectively.
Conclusion: Local and machine chicken egg whites have antifungal properties against C. albicans.

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