Introduction: Symptoms and complications of menopause affect menopausal women’s quality of life. In order to control these symptoms and improving their quality of life, this study was done to evaluate the effect of Glycyrriza glabra on quality of life in postmenopausal women.

Methods: This Randomized clinical trial was carried out between Octobers to March 2014 at Arastoo clinic in Arak. Samples were 60 postmenopausal women which were selected by convenient method and after obtaining informed consent were randomly allocated into two groups. The first group received three Glycyrriza glabra tablets (containing 380 mg extract) three times daily for one month at morning, noon and night. The second group received placebo. Quality of life was investigated by Menopause Quality of Life Questionnaire (MENQOL) before and one month after the intervention. Data was analyzed under SPSS V.16 using Chi-square, ANOVA, and Mann-Whitney tests.

Results: Both groups were similar in terms of demographic characteristics. Results indicated that before the intervention there was no significant difference among the two groups in total quality of life (p=0.001), and vasomotor (p=0.181), psychosocial (p=0.145), physical (p=0.711) and sexual (p=0.51) dimensions. But one month after the intervention there was significant difference among the two groups in total quality of life (p=0.001), and vasomotor (p=0.001), psychosocial (p=0.001) and physical (p=0.001) dimensions.

Conclusion: According to the results, consuming Glycyrriza glabra was effective in improving quality of life in menopausal women.