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Volume 8, Issue 1 (6-2018)
cmja 2018, 8(1): 2206-2217 |
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Khanzadeh N, Poozesh R, Nour Azar A. Investigating the Effect of Eight Weeks of Aerobic Exercise and Chlorella Algae Supplementation on Plasma Levels of Paraoxonase-1 and Lipid Hydroperoxide in Diabetic Male Rats. cmja 2018; 8 (1) :2206-2217
URL: http://cmja.arakmu.ac.ir/article-1-552-en.html
URL: http://cmja.arakmu.ac.ir/article-1-552-en.html
1- , Department of Physical Education and Sports Science, Faculty of Humanities and Educational Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran
2- 2- Assistant Professor in Exercise Physiology, Department of Physical Education and Sports Science, Faculty of Humanities and Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran , n.khanzade89@gmail.com
2- 2- Assistant Professor in Exercise Physiology, Department of Physical Education and Sports Science, Faculty of Humanities and Education, Tabriz Branch, Islamic Azad University, Tabriz, Iran , n.khanzade89@gmail.com
Abstract: (4375 Views)
Introduction: The aim of this research was to investigate the effect of eight weeks of aerobic exercise and Chlorella supplementation on paraoxonase-1 and lipid hydroperoxide in Wistar rats with type 2 diabetes.
Methods: The present study is an experimental research. 50 male Wistar rats with an average weight of 220±10 g were divided into 5 groups of normal control, diabetic control, diabetes + Chlorella supplementation, diabetes + aerobic exercise and combined (diabetes + Chlorella supplementation + aerobic exercise). The subjects were studied throughout an eight-week period and the levels of paraoxonase 1 and Lipid hydroperoxide were measured after this period. The data were analyzed using one-way ANOVA and Tukey’s post-hoc test.
Results: The results showed significant differences between the groups in terms of paraoxonase-1 level (P=0.001). Comparisons between the Chlorella supplementation and aerobic exercise groups (P=0.001), Chlorella supplementation and combined groups (P=0.001), and aerobic exercise and combined groups (P=0.007) also showed significant differences. Also, there were significant differences between the groups in terms of Lipid hydroperoxide (P=0.001) as significant differences between the Chlorella supplementation and aerobic exercise groups (P=0.005), the Chlorella supplementation and combined groups (P=0.001) and the aerobic exercise and combined groups (P=0.029).
Conclusion: Eight weeks of aerobic training and eight weeks of taking Chlorella can reduce Lipid hydroperoxide and increase paraoxonase-1 in rats with diabetes. However, a combination of exercise and Chlorella supplementation leads to better results.
Methods: The present study is an experimental research. 50 male Wistar rats with an average weight of 220±10 g were divided into 5 groups of normal control, diabetic control, diabetes + Chlorella supplementation, diabetes + aerobic exercise and combined (diabetes + Chlorella supplementation + aerobic exercise). The subjects were studied throughout an eight-week period and the levels of paraoxonase 1 and Lipid hydroperoxide were measured after this period. The data were analyzed using one-way ANOVA and Tukey’s post-hoc test.
Results: The results showed significant differences between the groups in terms of paraoxonase-1 level (P=0.001). Comparisons between the Chlorella supplementation and aerobic exercise groups (P=0.001), Chlorella supplementation and combined groups (P=0.001), and aerobic exercise and combined groups (P=0.007) also showed significant differences. Also, there were significant differences between the groups in terms of Lipid hydroperoxide (P=0.001) as significant differences between the Chlorella supplementation and aerobic exercise groups (P=0.005), the Chlorella supplementation and combined groups (P=0.001) and the aerobic exercise and combined groups (P=0.029).
Conclusion: Eight weeks of aerobic training and eight weeks of taking Chlorella can reduce Lipid hydroperoxide and increase paraoxonase-1 in rats with diabetes. However, a combination of exercise and Chlorella supplementation leads to better results.
Type of Study: Research |
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