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Volume 12, Issue 4 (Winter 2023 2023)
cmja 2023, 12(4): 13-21 |
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Javadikia M, Barjaste yazdi A, Khajei R, Hosein abadi M R. The Effect of 8 Weeks High-Intensity Interval Training and Portulaca Oleracea Supplement on Serum Level of TAC, MDA, CRP, TNF-α in Rats with Non-Alcoholic Fatty Liver Disease. cmja 2023; 12 (4) :13-21
URL: http://cmja.arakmu.ac.ir/article-1-912-en.html
URL: http://cmja.arakmu.ac.ir/article-1-912-en.html
1- Department of Physical Education, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
2- Department of Physical Education, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran ,barjaste.a7@gmail.com
2- Department of Physical Education, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran ,
Abstract: (970 Views)
Introduction: The aim of present study was to investigate the effect of eight weeks of high-intensity interval training (HIIT) and Portulaca Oleracea extract on on serum level of TAC, MDA, CRP, and TNF-α in rats with NAFLD.
Methods: 25 male Wistar randomly divided into five groups: healthy control, fatty liver control, HIIT, Portulaca Oleracea extract, and HIIT+Portulaca Oleracea extract. The rats were fed a high-fat diet for 12 weeks to induce NAFLD. Portulaca Oleracea supplement at 400 mg/kg was given to the experimental groups. HIIT was performed for 8 weeks, 5 sessions per week with 7 repetitions of 1 minute at 90% maximum speed and active rest intervals including 2 minutes of running at 20% maximum speed. To analyze the data, one-way analysis of variance and Tukey's post hoc test were used at the significance level of P < 0.05. All statistical calculations were done using SPSS20 statistical software.
Results: Serum Level of MDA in Portulaca Oleracea Extract and HIIT + Portulaca Oleracea groups were significantly lower than fatty liver control group. Serum level of TAC were significantly higher in Portulaca Oleracea Extract than healthy control and fatty liver control groups. Level of this index in HIIT+ Portulaca Oleracea Extract group was significantly higher than fatty liver control group. Serum Level of CRP and TNF-α in Portulaca Oleracea, HIIT and HIIT + Portulaca Oleracea groups were significantly lower than fatty liver control group.
Conclusions: It seems that long term HIIT and consumption of Portulaca Oleracea extract by improving peroxidation and antioxidant balance and reducing inflammatory factors in NAFLD subjects, can play an important role in controlling the progress of this disease.
Methods: 25 male Wistar randomly divided into five groups: healthy control, fatty liver control, HIIT, Portulaca Oleracea extract, and HIIT+Portulaca Oleracea extract. The rats were fed a high-fat diet for 12 weeks to induce NAFLD. Portulaca Oleracea supplement at 400 mg/kg was given to the experimental groups. HIIT was performed for 8 weeks, 5 sessions per week with 7 repetitions of 1 minute at 90% maximum speed and active rest intervals including 2 minutes of running at 20% maximum speed. To analyze the data, one-way analysis of variance and Tukey's post hoc test were used at the significance level of P < 0.05. All statistical calculations were done using SPSS20 statistical software.
Results: Serum Level of MDA in Portulaca Oleracea Extract and HIIT + Portulaca Oleracea groups were significantly lower than fatty liver control group. Serum level of TAC were significantly higher in Portulaca Oleracea Extract than healthy control and fatty liver control groups. Level of this index in HIIT+ Portulaca Oleracea Extract group was significantly higher than fatty liver control group. Serum Level of CRP and TNF-α in Portulaca Oleracea, HIIT and HIIT + Portulaca Oleracea groups were significantly lower than fatty liver control group.
Conclusions: It seems that long term HIIT and consumption of Portulaca Oleracea extract by improving peroxidation and antioxidant balance and reducing inflammatory factors in NAFLD subjects, can play an important role in controlling the progress of this disease.
Keywords: High Intensity Interval Training, Portulaca Oleracea extract, MDA, TAC, CRP, TNF-α, Non-Alcoholic Fatty Liver
Type of Study: Research |
Subject:
Physiology
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