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Volume 15, Issue 2 (8-2025)
cmja 2025, 15(2): 86-96 |
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Hussein Al-Shuwayli S N, Tofighi A, Jamali Gharakhanlou B, Shiri M R. Medium-term Effect of Resveratrol Supplementation and High-intensity Interval Training on Lipid Peroxidation and Some Oxidative Stress Indices in Men with Metabolic Syndrome. cmja 2025; 15 (2) :86-96
URL: http://cmja.arakmu.ac.ir/article-1-1042-en.html
URL: http://cmja.arakmu.ac.ir/article-1-1042-en.html
Sadegh Naser Hussein Al-Shuwayli1 
, Asghar Tofighi *2 , Bahram Jamali Gharakhanlou3 , Mohammad Reza Shiri4
, Asghar Tofighi *2 , Bahram Jamali Gharakhanlou3 , Mohammad Reza Shiri4
1- Urmia University
2- Urmia University ,a.tofighi@urmia.ac.ir
3- Tabriz University of Medical Sciences
4- Qazvin University of Medical Sciences
2- Urmia University ,
3- Tabriz University of Medical Sciences
4- Qazvin University of Medical Sciences
Abstract: (12 Views)
Introduction: Given the role of oxidative stress and inflammation in the pathophysiology of metabolic syndrome (MetS), combined interventions like exercise training and antioxidant supplements (e.g., resveratrol) can be an effective strategy for improving metabolic indices. The present study was designed to investigate the effect of combining high-intensity interval training (HIIT) and resveratrol supplementation on lipid profile and oxidative stress indices in men with MetS.
Methods: The present quasi-experimental study was conducted on 54 men aged 20 to 50 years with MetS. After providing written informed consent, participants were randomly assigned to one of four groups: Placebo (PLC), Resveratrol (RES), HIIT, and HIIT+RES. The exercise protocol was conducted over eight weeks at intensities ranging from 50-100% of heart rate reserve. Resveratrol (250 mg/day) or an identical placebo capsule was administered daily. Fasting blood samples were collected and analyzed before and after the intervention to measure lipid profiles, malondialdehyde (MDA), and total antioxidant capacity (TAC).
Results: The HIIT+RES group demonstrated significant reductions in Cholesterol, Triglycerides, LDL-C, and MDA levels (p≤0.05), alongside significant increases in HDL-C and TAC (p < 0.05). The combined intervention exhibited superior efficacy in improving these outcomes compared to the single-modality interventions (p < 0.05). While the HIIT and RES groups alone also indicated improvements in certain lipid markers, the magnitude of change observed in the combined group was statistically more pronounced.
Conclusion: The combination of HIIT and resveratrol is proposed as an effective non-pharmacological strategy for improving lipid profiles, reducing oxidative stress, and enhancing antioxidant capacity in patients with MetS. These findings underscore the importance of multifaceted interventions in the management of MetS.
Methods: The present quasi-experimental study was conducted on 54 men aged 20 to 50 years with MetS. After providing written informed consent, participants were randomly assigned to one of four groups: Placebo (PLC), Resveratrol (RES), HIIT, and HIIT+RES. The exercise protocol was conducted over eight weeks at intensities ranging from 50-100% of heart rate reserve. Resveratrol (250 mg/day) or an identical placebo capsule was administered daily. Fasting blood samples were collected and analyzed before and after the intervention to measure lipid profiles, malondialdehyde (MDA), and total antioxidant capacity (TAC).
Results: The HIIT+RES group demonstrated significant reductions in Cholesterol, Triglycerides, LDL-C, and MDA levels (p≤0.05), alongside significant increases in HDL-C and TAC (p < 0.05). The combined intervention exhibited superior efficacy in improving these outcomes compared to the single-modality interventions (p < 0.05). While the HIIT and RES groups alone also indicated improvements in certain lipid markers, the magnitude of change observed in the combined group was statistically more pronounced.
Conclusion: The combination of HIIT and resveratrol is proposed as an effective non-pharmacological strategy for improving lipid profiles, reducing oxidative stress, and enhancing antioxidant capacity in patients with MetS. These findings underscore the importance of multifaceted interventions in the management of MetS.
Keywords: High-Intensity Interval Training (HIIT), Lipid Profile, Malondialdehyde (MDA), Metabolic Syndrome (MetS), Oxidative Stress, Resveratrol, Total Antioxidant Capacity (TAC)
Type of Study: Research |
Subject:
Physiology
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