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Volume 15, Issue 3 (12-2025)
cmja 2025, 15(3): 0-0 |
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nazari Y, nazari A. Investigation of the Role of Exercise and Garlic Supplementation on Malondialdehyde and Total Antioxidant Capacity: A Systematic Review and Meta-Analysis. cmja 2025; 15 (3)
URL: http://cmja.arakmu.ac.ir/article-1-1044-en.html
URL: http://cmja.arakmu.ac.ir/article-1-1044-en.html
1- Department of Sports Sciences, Faculty of Humanities and Social Sciences, Golestan University, Gorgan, Iran , y.nazari53@gmail.com
2- Department of Physical Education, University of Saravan, Saravan, Iran
2- Department of Physical Education, University of Saravan, Saravan, Iran
Abstract: (11 Views)
Introduction: During exercise, the production of reactive oxygen species (ROS) increases, causing oxidative stress, which results from an imbalance between the production of ROS and the capacity of the body's antioxidant defense system. Garlic supplementation has been a topic of interest to researchers as a potential nutritional strategy for mitigating oxidative stress induced by exercise. Therefore, the present study aimed to investigate the role of exercise and garlic supplementation on malondialdehyde (MDA) and total antioxidant capacity through a systematic review and meta-analysis.
Methods: Articles published in Persian and English up to 2025 were searched in PubMed, ScienceDirect, Scopus, the Scientific Information Database (SID), and IranDoc databases and entered into the meta-analysis. Fixed and random effects models were used to meta-analyze the average effect size (difference in mean with 95% confidence interval) in the research on MDA and total antioxidant capacity (TAC) using Comprehensive Meta-Analysis (Version 2) software.
Results: A total of 10 studies that examined the role of exercise and garlic supplementation on oxidative stress index and TAC were meta-analyzed. The results of the meta-analysis indicated that garlic supplementation and exercise did not have a significant effect on MDA levels (ES=-0.50, 95% CI=-1.10 to 0.08, p=0.09) and TAC (ES=-0.50, 95% CI=-1.03 to 0.02, p=0.06).
Conclusion: The results of the present meta-analysis demonstrated that the combination of regular exercise and garlic supplementation, despite the observed trends towards improving antioxidant status, did not have a statistically significant effect on MDA levels and TAC in the reviewed studies.
Methods: Articles published in Persian and English up to 2025 were searched in PubMed, ScienceDirect, Scopus, the Scientific Information Database (SID), and IranDoc databases and entered into the meta-analysis. Fixed and random effects models were used to meta-analyze the average effect size (difference in mean with 95% confidence interval) in the research on MDA and total antioxidant capacity (TAC) using Comprehensive Meta-Analysis (Version 2) software.
Results: A total of 10 studies that examined the role of exercise and garlic supplementation on oxidative stress index and TAC were meta-analyzed. The results of the meta-analysis indicated that garlic supplementation and exercise did not have a significant effect on MDA levels (ES=-0.50, 95% CI=-1.10 to 0.08, p=0.09) and TAC (ES=-0.50, 95% CI=-1.03 to 0.02, p=0.06).
Conclusion: The results of the present meta-analysis demonstrated that the combination of regular exercise and garlic supplementation, despite the observed trends towards improving antioxidant status, did not have a statistically significant effect on MDA levels and TAC in the reviewed studies.
Type of Study: Review Paper |
Subject:
Medicinal Plants
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