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1- Department of Physical Education and Sport Sciences, QaS.C., Islamic Azad University, Qaemshahr, Iran
2- Department of Physical Education and Sport Sciences, QaS.C., Islamic Azad University, Qaemshahr, Iran ,amir.taghipoor@iau.ac.ir
2- Department of Physical Education and Sport Sciences, QaS.C., Islamic Azad University, Qaemshahr, Iran ,
Abstract: (91 Views)
Introduction: Alzheimer's disease is characterized by the abnormal accumulation of amyloid beta peptide in the brain and activation of the amyloidogenic pathway through the enzymes β-secretase and γ-secretase. The present study aimed to determine the protective effect of interval training combined with resveratrol (RSV) consumption on the expression of γ and β secretase in the hippocampus of Alzheimer's rats with amyloid beta.
Materials and Methods: In this experimental study, 35 male Wistar rats with an average weight of 223.17 ± 9.08 g were obtained from the Pasteur Institute and randomly divided into five groups, including control (NO), Alzheimer (AD), Alzheimer-training (ADT), Alzheimer-resveratrol (ADRSV), and Alzheimer- training-resveratrol (ADTRSV). Alzheimer's induction was performed by injecting Aβ1-42 into the hippocampus. The interval training consisted of treadmill running at a gradual intensity (30-40 m/min) for 8 weeks, 5 days a week. Resveratrol was orally administered at a dose of 20 mg/kg body weight to the animals during the intervention. For statistical analysis, one-way analysis of variance and Tukey's post hoc test were used.
Results: The results of the study showed a significant increase in the rate of changes in γ-secretase gene expression in the AD (p=0.0001), ADT (p=0.002), and ADRSV (p=0.0001) groups compared to the control group, as well as a significant decrease in the ADT (p=0.024) and ADTRSV (p=0.0001) groups compared to AD. The results showed that there was a significant increase in the rate of changes in β-secretase gene expression in the AD (p=0.0001), ADT (p=0.001), and ADRSV (p=0.0001) groups compared to the control group, as well as a significant decrease in the ADT (p=0.036) and ADTRSV (p=0.0001) groups compared to AD.
Conclusion: The results of the present study could have potential application in the development of non-invasive strategies to prevent or control the progression of Alzheimer's disease.
Materials and Methods: In this experimental study, 35 male Wistar rats with an average weight of 223.17 ± 9.08 g were obtained from the Pasteur Institute and randomly divided into five groups, including control (NO), Alzheimer (AD), Alzheimer-training (ADT), Alzheimer-resveratrol (ADRSV), and Alzheimer- training-resveratrol (ADTRSV). Alzheimer's induction was performed by injecting Aβ1-42 into the hippocampus. The interval training consisted of treadmill running at a gradual intensity (30-40 m/min) for 8 weeks, 5 days a week. Resveratrol was orally administered at a dose of 20 mg/kg body weight to the animals during the intervention. For statistical analysis, one-way analysis of variance and Tukey's post hoc test were used.
Results: The results of the study showed a significant increase in the rate of changes in γ-secretase gene expression in the AD (p=0.0001), ADT (p=0.002), and ADRSV (p=0.0001) groups compared to the control group, as well as a significant decrease in the ADT (p=0.024) and ADTRSV (p=0.0001) groups compared to AD. The results showed that there was a significant increase in the rate of changes in β-secretase gene expression in the AD (p=0.0001), ADT (p=0.001), and ADRSV (p=0.0001) groups compared to the control group, as well as a significant decrease in the ADT (p=0.036) and ADTRSV (p=0.0001) groups compared to AD.
Conclusion: The results of the present study could have potential application in the development of non-invasive strategies to prevent or control the progression of Alzheimer's disease.
Type of Study: Research |
Subject:
Physiology
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