Introduction: The most common syndrome in women is PMS. Premenstrual syndrome is one or more periodic large collection symptoms before menstrual cycle, which lead to degree of changes in personal activities and active lifestyle for him and followed by a period with no symptom is generated. Hypericum Perforatum L. and vitex agnus are two herbal remedies that have been used to relieve symptoms of premenstrual syndrome. The purpose of this study is determination of the effect of Hypericum Perforatum L. and vitex agnus and VitE on Premenstural Syndrome.

  Methods: This is a one-stage clinical trials . The study sample included 210 women with PMS were placed in three groups of 70 (Simple randomized) . In the first group , Vitex tablets second group , Hypericum Perforatum L. tablets and the control group were given vitamin E for 2 months . Before and 2 months after the intervention were compared with standard chart of PMS . Intensity of Symptoms were identified with the number 1 ( no symptoms), 2 ( mild symptoms ), 3 ( moderate symptoms ) and 4 ( severe symptoms ). The results were analyzed using SPSS software . In the study of descriptive and inferential statistics including Mann -Whitney U test, Kolmogrov Smirinov, test t paired, chi-square test , Fisher's exact test and one -way ANOVA was used for diffraction . The significance level for all tests p<0.05 was considered.

  Results : Measure of average intensity of Symptoms were received in Hypericum Perforatum L. group 62.03 ± 31.54 before intervention to 38.76 ± 12.11 after the intervention in Vitex group of 61.23 ± 30.54 to 25.25 ± 17.78 and the vitamin E group, from 61.24 ± 32.04 to 54.9 ± 19.24. Compare average intensity of Symptoms in the Hypericum Perforatum L. group and in vitamin E group (p<0.005) , also Vitex group and in vitamin E group ( p<0.001 ) and in the Hypericum Perforatum L. group and Vitex group ( p<0.001 ) before and after intervention Showed that has increased but this is a dramatic decrease in Vitex group.

  Conclusion: This study showed that Vitex a good therapeutic effect for Premenstrual syndrome treatment and it can be used as an effective treatment.