Introduction: Nausea and vomiting are among the most common complications of
Caesarean section and may cause suture dehiscence, esophageal perforation,
gastric aspiration, and delay in hospital discharge. The aim of this study was
to compare the antiemetic effect of Ginger, Gabapentin, and Ondansetron for
prevention of nausea and vomiting after cesarean section by spinal anesthesia.
Methods: This randomized, double-blind placebo controlled clinical trial was
done on 208 women undergoing elective cesarean section. After taking written
informed consents, they were divided into four equal groups. 300 mg Gabapentin,
8 mg Ondansetron, 1 gr Ginger, and placebo were administered to each group.
Before performing spinal anesthesia and after the operation in recovery, and
also in 2, 4, and 6 hours intervals after the surgery, nausea and vomiting were
recorded based on a four point scale. Data was analyzed by SPSS 19 using one
way ANOVA, independent t-test and Chi square.
Results: There were no significant differences among the four groups
according to age, gravidity mothers` mean atrial pressure and heart rate
before and during surgery, newborns` APGAR score and mothers` consciousness.
Nausea and vomiting in Gabapentin (0.28±0.34), Ondansetron (0.28±0.25), and
Ginger (0.27±0.85) groups were significantly less than placebo group (1±0.22)
(p=0.01), whereas there were no significant differences among the three
groups (p=0.05).
Conclusion: Using Gabapentin, Ondansetron and Ginger with the same antiemetic
effect are appropriate for women undergoing cesarean section.
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