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Volume 8, Issue 2 (9-2018)
cmja 2018, 8(2): 2304-2316 |
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mir A, azarbayjani M A, matin homai H, Fanaei H. Effect of Resistance and Aerobic Exercises with Different Intensities on BDNF & TrkB Receptor Gene Expression in Ovariectomized Mice. cmja 2018; 8 (2) :2304-2316
URL: http://cmja.arakmu.ac.ir/article-1-574-en.html
URL: http://cmja.arakmu.ac.ir/article-1-574-en.html
1- , Department of Exercise Physiology, Faculty of Physical Education, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
2- , PhD Candidate in Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education, Central Tehran Branch, Islamic Azad University, Tehran, Iran. ,ali.azarbayjani@gmail.com
3- , PhD in Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
4- , PhD in Physiology, Department of Physiology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
2- , PhD Candidate in Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education, Central Tehran Branch, Islamic Azad University, Tehran, Iran. ,
3- , PhD in Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
4- , PhD in Physiology, Department of Physiology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Abstract: (4756 Views)
Introduction: This study aimed to investigate the effect of resistance and aerobic exercises with different intensities on BDNF & TrkB receptor gene expression in ovariectomized mice.
Methods: Sixty 6 to 8-month old mice with average weight of 230 ±10 g were randomly divided into six 10-member groups: ovariectomized + high-intensity resistance exercises, ovariectomized + low-intensity resistance exercises, ovariectomized + high-intensity swimming exercises, ovariectomized + low-intensity swimming exercises, control and sham. The animals in the exercise groups performed low- and high-intensity exercises for 8 weeks, one session a day, 3 days a week. After the training protocol, the animals' hippocampus tissues were removed. Quantitative Real-time RT-PCR was used to determine the changes occurred in BDNF and TrkB gene expression. The data were analyzed by SPSS 23 using ANOVA at the significant level of α = 0.05.
Results: BDNF gene expression significantly increased in the high-intensity resistance exercise group (P<0.036), but the difference was not significant in the low-intensity resistance exercise (P<0.975), high-intensity swimming exercise (P<0.141) and low-intensity swimming groups (P = 0.998) compared to the control group. TrkB receptor gene expression increased in the high-intensity resistance exercise (P<0.036) and swimming exercise groups (P<0.002), but the difference was not significant in the low-intensity resistance exercise (P<0.442) and swimming exercise groups (P<0.688).
Conclusion: High-intensity swimming exercise increased BDNF and TrkB receptor gene expression. However, high-intensity resistance exercise is likely to offer better results.
Methods: Sixty 6 to 8-month old mice with average weight of 230 ±10 g were randomly divided into six 10-member groups: ovariectomized + high-intensity resistance exercises, ovariectomized + low-intensity resistance exercises, ovariectomized + high-intensity swimming exercises, ovariectomized + low-intensity swimming exercises, control and sham. The animals in the exercise groups performed low- and high-intensity exercises for 8 weeks, one session a day, 3 days a week. After the training protocol, the animals' hippocampus tissues were removed. Quantitative Real-time RT-PCR was used to determine the changes occurred in BDNF and TrkB gene expression. The data were analyzed by SPSS 23 using ANOVA at the significant level of α = 0.05.
Results: BDNF gene expression significantly increased in the high-intensity resistance exercise group (P<0.036), but the difference was not significant in the low-intensity resistance exercise (P<0.975), high-intensity swimming exercise (P<0.141) and low-intensity swimming groups (P = 0.998) compared to the control group. TrkB receptor gene expression increased in the high-intensity resistance exercise (P<0.036) and swimming exercise groups (P<0.002), but the difference was not significant in the low-intensity resistance exercise (P<0.442) and swimming exercise groups (P<0.688).
Conclusion: High-intensity swimming exercise increased BDNF and TrkB receptor gene expression. However, high-intensity resistance exercise is likely to offer better results.
Type of Study: Applicable |
Subject:
Physiology
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