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Alavi F, Seify F, Nabilpour M. Effect of 8 Weeks High Intensity Interval Training with Sodium Citrate Supplementation on PGC-1α and TFAM Expression. cmja 2023; 12 (4) :22-32
URL: http://cmja.arakmu.ac.ir/article-1-900-en.html

Introduction: High intensity interval training can promote PGC-1α and TFAM key regulator of mitochondrial biogenesis. Then the purpose of this investigation is to examine the effect of high intensity interval training whit supplementation of sodium citrate on PGC-1α and TFAM expression in soleus muscle of Wistar rats.

Methods: 24 Wistar rats were randomly divided into 3 groups of control, training and training with sodium citrate supplementation. Both training and training with sodium citrate supplementation groups performed high intensity interval training for 8 weeks, five days a week, with the intensity of 50% to 90% maximum running speed on rodent treadmill. The training with supplement group were treated with a dose (15 mmol/L) of sodium citrate by drinking water per day for 8 weeks. Statistical evaluations of the experiments were investigated by applying One-Way ANOVA and Tukey’s post hoc analysis with a statistical level of P < 0.05. Cohen’s d also was calculated to compare groups.

Results: Findings indicated significant differences in PGC-1α and TFAM protein level in both training and training with supplement groups compared to control group (P = 0.001). Results about sodium citrate supplementation also showed significant differences in training with supplementation group compared to training group (P = 0.005).
Conclusions: It seems sodium citrate supplementation can induce expression of PGC-1α and TFAM and increases level of PGC-1α and TFAM proteins.