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Volume 14, Issue 1 (4-2024)
cmja 2024, 14(1): 29-37 |
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naderi A, saremi A, Afarinesh Khaki M R. The effect of 12 weeks of endurance training with sumac intake on the serum levels of nitric oxide and interleukin-1 beta in Alzheimer's male rats. cmja 2024; 14 (1) :29-37
URL: http://cmja.arakmu.ac.ir/article-1-974-en.html
URL: http://cmja.arakmu.ac.ir/article-1-974-en.html
1- Ph.D., Student in Exercise Physiology, Department of Physical Education, Faculty of Humanities, Islamic Azad University Borujerd Branch, Borujerd, Iran
2- Professor of Exercise Physiology, Department of Sports Science, Faculty of Physical Education, Arak University, Arak, Iran ,a-saremi@araku.ac.ir
3- Associate Professor, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
2- Professor of Exercise Physiology, Department of Sports Science, Faculty of Physical Education, Arak University, Arak, Iran ,
3- Associate Professor, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
Abstract: (665 Views)
Introduction: Alzheimer's is one of the most common dementia diseases. Exercise along with antioxidant substances can prevent the progress of this condition. Therefore, the aim of this study was to investigate the effect of 12 weeks of endurance training with sumac intake on the serum levels of nitric oxide and interleukin-1 beta in Alzheimer's male rats.
Materials and methods: In this experimental study, 35 male Wistar rats were randomly divided into 5 groups (healthy control, Alzheimer's, Alzheimer's with endurance exercise, Alzheimer's with sumac, Alzheimer's with endurance exercise and sumac ). In order to induce Alzheimer's disease, 8 mg of trimethyl tin chloride was injected. Sumac powder was used at a ratio of 10%. Endurance swimming exercises in water were 5 days a week and lasted 15 to 60 minutes in each session. 48 hours after the last training session, interleukin-1 beta and nitric oxide serum levels were measured by ELISA method. The data were analyzed by one-way ANOVA and Dunnett's test at a significance level of P<0.05.
Findings: The level of interleukin-1 beta in the sumac + endurance training group was lower than the other groups, and the nitric oxide levels in the sumac and endurance training group were significantly higher than the Alzheimer's group (P=0.001). However, the amount of nitric oxide in the sumac group with endurance training was not significantly different from the healthy group (P<0.05).
Conclusion: The results suggest that endurance exercise and taking sumac is associated with the improvement of inflammatory factors and the combination of these two interventions leads to a doubling of the improvement.
Materials and methods: In this experimental study, 35 male Wistar rats were randomly divided into 5 groups (healthy control, Alzheimer's, Alzheimer's with endurance exercise, Alzheimer's with sumac, Alzheimer's with endurance exercise and sumac ). In order to induce Alzheimer's disease, 8 mg of trimethyl tin chloride was injected. Sumac powder was used at a ratio of 10%. Endurance swimming exercises in water were 5 days a week and lasted 15 to 60 minutes in each session. 48 hours after the last training session, interleukin-1 beta and nitric oxide serum levels were measured by ELISA method. The data were analyzed by one-way ANOVA and Dunnett's test at a significance level of P<0.05.
Findings: The level of interleukin-1 beta in the sumac + endurance training group was lower than the other groups, and the nitric oxide levels in the sumac and endurance training group were significantly higher than the Alzheimer's group (P=0.001). However, the amount of nitric oxide in the sumac group with endurance training was not significantly different from the healthy group (P<0.05).
Conclusion: The results suggest that endurance exercise and taking sumac is associated with the improvement of inflammatory factors and the combination of these two interventions leads to a doubling of the improvement.
Type of Study: Research |
Subject:
Physiology
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