Volume 6, Issue 1 (6-2016)                   cmja 2016, 6(1): 1452-1460 | Back to browse issues page

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darabi S, hasanvand A, nourollahi A. Effects of garlic extract, olive leaf extract, nettle extract on serum inflammatory markers hsCRP and IL-6 and TNF-α in rats with diabetes. cmja. 2016; 6 (1) :1452-1460
URL: http://cmja.arakmu.ac.ir/article-1-242-en.html
Tehran University of Medical Sciences, International Campus (TUMS- IC),Tehran, Iran , dr.hasanvand@yahoo.com
Abstract:   (3300 Views)

Introduction: It has been demonstrated that the inflammatory markers such as IL-6, TNF-α and CRP are increased in STZ-diabetic rats. The present study is to investigate the effects of medicinal plants used in traditional medicine, including garlic extract; nettle leaves extract and olive extract on serum hsCRP and IL-6 and TNF-α on the rats with diabetes.
Methods: Diabetes was induced in male wistar rats by single injection streptozotocin (60 mg/kg). Garlic extract, nettle leaves extract and olive extract were used one day after induction of diabetes until three weeks after STZ-diabetes induction. In this study the animals were divided into five groups: control, diabetic, diabetic + garlic extract (50 mg / kg), diabetes + Nettle leaf extract (30 mg / kg), and diabetes + Olive extract (30 mg / kg). After 21 days, serum levels of inflammatory factors were measured using ELISA kits.

Results: The results showed that the serum levels of hsCRP and IL-6 and TNF-α in the target groups, the use of medicinal plants extracts, as compared to untreated diabetics have significantly decreased.
Conclusion: The results showed that administration of garlic extract, nettle extract and olive extract significantly attenuated levels inflammatory markers such as IL-6, TNF-α and CRP in diabetic rats.

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Type of Study: Research |

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