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Volume 15, Issue 3 (12-2025)
cmja 2025, 15(3): 0-0 |
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Mousavi Amin M, Farajtabar Behrestaq S, Taghipoor A, Askari B, Janbarari F Z. Effect of aerobic exercise and resveratrol on the expression of Fibrillin-1 and Asprosin in adipose tissue of NAFLD rats. cmja 2025; 15 (3)
URL: http://cmja.arakmu.ac.ir/article-1-1049-en.html
URL: http://cmja.arakmu.ac.ir/article-1-1049-en.html
Mohsen Mousavi Amin1 
, Saqqa Farajtabar Behrestaq *2 , Amir Taghipoor1 , Babisan Askari1 , Fatemeh Zahra Janbarari1
, Saqqa Farajtabar Behrestaq *2 , Amir Taghipoor1 , Babisan Askari1 , Fatemeh Zahra Janbarari1
1- Department of Physical Education and Sport Sciences, QaS.C., Islamic Azad University, Qaemshahr, Iran
2- Department of Physical Education and Sport Sciences, QaS.C., Islamic Azad University, Qaemshahr, Iran ,s.faraj.b@iau.ac.ir
2- Department of Physical Education and Sport Sciences, QaS.C., Islamic Azad University, Qaemshahr, Iran ,
Abstract: (15 Views)
Background: Non‐alcoholic fatty liver disease (NAFLD) is associated with increased production/deposition of collagen and extracellular matrix. The present study aimed to investigate the effect of aerobic exercise and resveratrol on the expression of Fibrillin-1 and Asprosin in adipose tissue of NAFLD rats.
Materials and Methods: This experimental study involved 35 Wistar male rats, divided into two groups: NAFLD (n=28) and Control-Normal (n=7). The NAFLD was induced in rats with a high-fat diet, and then the rats were subdivided into four subgroups: NAFLD, TRNAF, SUPNAF, and TRSUPNAF. Training groups have performed a running program on a motor-driven treadmill for eight weeks. Resveratrol (20 mg/kg) was injected into the SUPNAF and TRSUPNAF groups. Then, 48 hours after the last training session, the rats were anesthetized; their hearts were excised and immediately frozen in liquid nitrogen, then stored at -80°C for measurement of the indices. In addition, statistical analysis was performed using a one-way analysis of variance, and significance was accepted at p ≤ 0.05.
Results: Induction of NAFLD was associated with increased expression of Fibrillin-1 and Asprosin. Significant reductions of these genes in NAFLDT (p = 0.037, p = 0.047, respectively) and NAFLDTRSV (p = 0.0001; both) groups compared to the NAFLD. Furthermore, the NAFLDTRSV showed significantly lower expression compared to the NAFLDT (p = 0.037, p = 0.047) and NAFLDRSV (p = 0.007, p = 0.026) (p ≤ 0.05).
Conclusion: Exercise training along with resveratrol could improve adipose tissue disorders caused by NAFLD by significantly reducing the expression of Fibrillin-1 and Asprosin. However, the effect of resveratrol alone is not effective and more research is needed.
Materials and Methods: This experimental study involved 35 Wistar male rats, divided into two groups: NAFLD (n=28) and Control-Normal (n=7). The NAFLD was induced in rats with a high-fat diet, and then the rats were subdivided into four subgroups: NAFLD, TRNAF, SUPNAF, and TRSUPNAF. Training groups have performed a running program on a motor-driven treadmill for eight weeks. Resveratrol (20 mg/kg) was injected into the SUPNAF and TRSUPNAF groups. Then, 48 hours after the last training session, the rats were anesthetized; their hearts were excised and immediately frozen in liquid nitrogen, then stored at -80°C for measurement of the indices. In addition, statistical analysis was performed using a one-way analysis of variance, and significance was accepted at p ≤ 0.05.
Results: Induction of NAFLD was associated with increased expression of Fibrillin-1 and Asprosin. Significant reductions of these genes in NAFLDT (p = 0.037, p = 0.047, respectively) and NAFLDTRSV (p = 0.0001; both) groups compared to the NAFLD. Furthermore, the NAFLDTRSV showed significantly lower expression compared to the NAFLDT (p = 0.037, p = 0.047) and NAFLDRSV (p = 0.007, p = 0.026) (p ≤ 0.05).
Conclusion: Exercise training along with resveratrol could improve adipose tissue disorders caused by NAFLD by significantly reducing the expression of Fibrillin-1 and Asprosin. However, the effect of resveratrol alone is not effective and more research is needed.
Type of Study: Research |
Subject:
Physiology
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