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Volume 15, Issue 2 (8-2025)
cmja 2025, 15(2): 0-0 |
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Moradisafar M, heidarianpour A, panahabadi M, Naderi A. Effect of 12 Weeks of Aerobic Exercise and Hydroethanolic Extract on Serum Levels of Insulin, Phosphatidylinositol-Specific Phosphorylase, and Glypican-4 in Type 1 Diabetes Rats. cmja 2025; 15 (2)
URL: http://cmja.arakmu.ac.ir/article-1-1034-en.html
URL: http://cmja.arakmu.ac.ir/article-1-1034-en.html
1- Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Bu Ali Sina University, Hamadan, Iran
2- Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Bu Ali Sina University, Hamadan, Iran ,a.heidarianpour@basu.ac.ir
3- Department of Sports Pathology and Corrective Exercises, Islamic Azad University, North Tehran Branch, Tehran, Iran
4- Department of Physical Education and Sport Sciences, National University of Skill, Tehran, Iran
2- Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Bu Ali Sina University, Hamadan, Iran ,
3- Department of Sports Pathology and Corrective Exercises, Islamic Azad University, North Tehran Branch, Tehran, Iran
4- Department of Physical Education and Sport Sciences, National University of Skill, Tehran, Iran
Abstract: (30 Views)
Introduction: Glypican-4 (CPC-4) is an adipokine that increases insulin signaling. By binding to phosphatidylinositol, it facilitates the binding of specific phosphorylase to the cell membrane, thereby enhancing insulin signaling. Exercise increases insulin sensitivity, and chamomile exerts marked antioxidant effects. The present study aimed to assess the effect of aerobic exercise combined with chamomile extract on glypican-4, insulin, and glycosylphosphatidylinositol-specific phospholipase D (GPLD1).
Methods: In this experimental study, 24 male Wistar rats were induced with Type 1 diabetes by injecting streptozotocin (STZ) in a saline solution. They were randomly assigned to four groups: (control group, exercise group, extract group, and extract + exercise group). After receiving chamomile extract (receiving 200 mg of chamomile extract per kilogram of body weight per day for 12 weeks, five days a week, 60 minutes per session), serum levels of glypican, fasting blood insulin, phosphatidylinositol-glycan-specific phospholipase, and glypican-4 were measured by the ELISA method at the end of the study. The collected data were analyzed in SPSS software (version 29) using one-way ANOVA and Tukey's post hoc tests. A p-value of less than 0.05 was considered statistically significant.
Results: Compared to the control group, serum insulin levels were significantly lower in the exercise group and the extract group. Nonetheless, changes in glypican-4 and phosphatidylinositol-specific phospholipase D levels were not significant.
Conclusion: This study sought to reduce the levels of phosphatidylinositol-specific phosphorylase in diabetic mice by aerobic exercise and extract intake. However, the reduction was not statistically significant, which is related to serum insulin levels. Furthermore, aerobic exercise and extract intake failed to regulate serum glypican-4 levels in type 1 diabetic rats.
Methods: In this experimental study, 24 male Wistar rats were induced with Type 1 diabetes by injecting streptozotocin (STZ) in a saline solution. They were randomly assigned to four groups: (control group, exercise group, extract group, and extract + exercise group). After receiving chamomile extract (receiving 200 mg of chamomile extract per kilogram of body weight per day for 12 weeks, five days a week, 60 minutes per session), serum levels of glypican, fasting blood insulin, phosphatidylinositol-glycan-specific phospholipase, and glypican-4 were measured by the ELISA method at the end of the study. The collected data were analyzed in SPSS software (version 29) using one-way ANOVA and Tukey's post hoc tests. A p-value of less than 0.05 was considered statistically significant.
Results: Compared to the control group, serum insulin levels were significantly lower in the exercise group and the extract group. Nonetheless, changes in glypican-4 and phosphatidylinositol-specific phospholipase D levels were not significant.
Conclusion: This study sought to reduce the levels of phosphatidylinositol-specific phosphorylase in diabetic mice by aerobic exercise and extract intake. However, the reduction was not statistically significant, which is related to serum insulin levels. Furthermore, aerobic exercise and extract intake failed to regulate serum glypican-4 levels in type 1 diabetic rats.
Keywords: : Type 1 diabetes, insulin, glypicon-4, chamomile, endurance exercise, phosphatidylinositol special phosphorylase D
Type of Study: Research |
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