Volume 3, Number 3 (12-2013)                   cmja 2013, 3(3): 516-528 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

roshanai K, Heydarieh N, bostani A. Effect Of Extract of Seed Ziziphus Jujuba on Anxiety in Male Rats. cmja. 2013; 3 (3) :516-528
URL: http://cmja.arakmu.ac.ir/article-1-116-en.html

Animal physiology graduate student Qom islamic Azad University , Azin_bostani@yahoo.com
Abstract:   (4603 Views)

  Introduction: Anxiety disorder is a common, problem that often associated with physiological symptoms. Because of synthetic drugs and medications possess enormous side effects, hence the present study was to investigate anxiolytic effect of seed of Ziziphus jujuba extract (SZJE) in rat using in Elevated plus maze (EPM).

  Methods: Anxiety was measured by the number of entries and duration spent in open and close arm of the EPM following administration of the extracts intraperitoneally (i.p).Total number of entries was measured as an index of locomotor activity. Diazepam (1.0 mg/kg, i.p.) was used as the positive control.

  Results: The SZJE at the dosage 50-100mg/kg increased the percentage of time-spent (p<0/05, p<0/001) and at the dosage 100mg/kg increased the percentage of arm entries in the open arms of the EPM ( p<0/001) and decreased the percentage of time-spent and the percentage of arm entries in the closed arms of the EPM. The effect of The SZJE at the dosage 100mg/kg did not differ significantly from diazepam. Ad ministration of the extracts in these doses had no effect on locomotor activity.

Conclusion: These results suggested that extract seed of Ziziphus jujuba possessed anxiolytic effect at 50-100 mg/kg doses.

Full-Text [PDF 701 kb]   (1487 Downloads)    
Type of Study: Research |

Add your comments about this article : Your username or email:
Write the security code in the box

Send email to the article author


© 2015 All Rights Reserved | Complementary Medicine Journal of faculty of Nursing & Midwifery

Designed & Developed by : Yektaweb